Kemi
The Chemistry Research Group conducts fundamental and applied research in a variety of areas, and many of the research projects have strong connections with Chemical Biology. The sustainable development and application of chemistry is a common theme in our research, which drives many of our projects in green chemistry and energy, molecules of medicinal and biological interest, biophysical and protein chemistry, enzyme catalysis, and chemical characterization. Research efforts in these areas, for example, resulted in the development of new medicines and new chemical tools for studying biological molecules and processes, and molecular interactions. Through these research activities the next generation of scientists receive a training in fundamental and cutting edge theory, together with modern practical laboratory techniques and skills.
Key areas of interest include:
- Biophysical and biological chemistry (protein structure and interactions by NMR, hydrogen bonding, oligomerization, fibril formation and gelation)
- Enzymology (catalysis, hydrolytic enzymes)
- Energy and sustainability (solar cell chemistry, biodegradable plastics, electrochemistry)
- Organic synthesis and chemical biology (methods development, bioactive compounds and new medicines, bioconjugates, biopolymers, drug delivery systems)
- Proteomics and Metabolomics (chemical characterization of biological processes, mass spectrometry, NMR and multivariate analysis)
- Analytical chemistry (chromatography and mass spectrometry methods, sensor development)
- Surface chemistry (development and characterization of peptoid nanosheets, molecular probes and interactions)
As an interdisciplinary hub, the Chemistry Group plays a key role in collaborative research projects conducted with internal and external academic partners working in areas such as; molecular, medical, and environmental biology, as well as mathematics and physics. The group is a founding member of the Roskilde University Center for Frustrated Molecular Interactions, which drives and conducts larger scale research programs. In addition to these activities, the group has many collaborations with major Danish and international research institutions and industrial partners.
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Kontakt
William Goldring, lektor, faggruppeleder, goldring@ruc.dk
Forskere
Frederik Diness, lektor, diness@ruc.dk
William Goldring, lektor, goldring@ruc.dk
Jeppe Kari, lektor, jkari@ruc.dk
Torben Lund, lektor, tlund@ruc.dk
Anders Malmendal, lektor, amalm@ruc.dk
Biljana Mojsoska, lektor, biljana@ruc.dk
Trine Holm Freiesleben, videnskabelig assistent, tholmf@ruc.dk
Jens Christian Sidney Schönbeck, videnskabelig assistent, jechsc@ruc.dk
Poul Erik Hansen, professor emeritus, poulerik@ruc.dk
Søren Hvidt, lektor emeritus, hvidt@ruc.dk
Jens Josephsen, lektor emeritus, phjens@ruc.dk
John Mortensen, lektor emeritus, john@ruc.dk
Jens Spanget-Larsen, lektor emeritus, spanget@ruc.dk
Forskere i faggruppen Kemi findes på Roskilde Universitets Forskningsportal
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Based in a new building equipped with modern infra-structure, chemistry researchers in the DSC work with state-of-the-art instrumentation and analytical facilities, such as:
Mass Spectrometry
Associate Prof. Torben Lund (tlund@ruc.dk)
Associate Prof. Biljana Mojsoska (biljana@ruc.dk)
Rosa Jersie-Christensen, PhD (rrj@ruc.dk)LC-MS
LTQ-XL Thermo Finnigan linear ion-trap mass spectrometer with a HESII electro spray ion source, coupled to a Dionex Ultimate 3000 UHPLC and a diode array detector.
Instrument use: Analysis of ruthenium dyes, natural products, intact proteins, peptides, organic reaction mixtures.Q Exactive Plus, high resolution mass spectrometer coupled to a Dionex Ultimate 3000 nano-HPLC.
Instrument use: Proteomics and exact mass determinations.GC-MS
Thermo Scientific Trace 1300 GC coupled to a ISQ-7000 EI-MS and a TDC detector. The instrument includes a Triplus RSH autosampler with PTV and head-space injection.
Instrument use: PCB and gas-molecule detection (H2, CO, CO2…).Nuclear Magnetic Resonance (NMR) Spectrometer
Associate Prof. William Goldring (goldring@ruc.dk)
Associate Prof. Anders Malmendal (amalm@ruc.dk)
Operator: Annette Christensen (acis@ruc.dk)Bruker Ascend 400 MHz, including auto-sampler and BCU II variable temperature control
Instrument use: Analysis of synthesis and natural products, biological material, and molecular complexes. Methods include, structure characterization and elucidation using a variety of routine and non-routine one- and two-dimensional experiments.Dynamic Light Scattering (DLS)
Associate Prof. Søren Hvidt (hvidt@ruc.dk)
Malvern Zetasizer Nano-S
Instrument use: Analysis of nanoparticles, including materials and biological complexes, for particle size measurement and polydispersity determination.Other instruments
The section is also equipped with a number of other instruments, such as infrared and UV spectrometers, preparative and analytical chromatographic equipment (HPLC, radial LC, size exclusion), rheometers (Bohlin VOR and Haake RS100), calorimeters (ITC and DSC), photochemical lamps (400 and 125 W medium pressure Hg) and reaction vessels, and chemical computation facilities (Gaussian and Macromodel).
Publikationer
A new sesquiterpene lactone from the leaves of Panax vietnamensis Ha et Grushv. (Vietnamese ginseng)
Le, H. K., Phan, T. T., Nguyen, T. M. N., Nguyen, T. C., Tran, C. L., Hansen, P. E. & That, Q. T., 2023, I: Natural Product Research. 37, 21, s. 3580-3587 8 s.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
Antibiotic fingerprints: Proteomics profiling of Pseudomonas aeruginosa persister cells
Mojsoska, B., 27 nov. 2023.Publikation: Konferencebidrag › Konferenceabstrakt til konference › Forskning › peer review
Electrochemical sensors for screening of tyrosine and tryptophan as biomarkers for diseases: A narrative review
Nasimi, H., Madsen, J. S., Zedan, A. H., Malmendal, A., Osther, P. J. S. & Alatraktchi, F. A. Z. A., jul. 2023, I: Microchemical Journal. 190, 108737.Publikation: Bidrag til tidsskrift › Review › peer review
Aktiviteter
Protein Signaling - in time and space
Biljana Mojsoska (Deltager)
27 nov. 2023 → 1 dec. 2023Aktivitet: Deltagelse i eller arrangering af en begivenhed › Deltagelse i workshop, seminar og kursus
European Scientific Conference on Applied Infectious Disease Epidemiology
Biljana Mojsoska (Deltager)
22 nov. 2023 → 24 nov. 2023Aktivitet: Deltagelse i eller arrangering af en begivenhed › Deltagelse i workshop, seminar og kursus
Mere viden
Kan nanomaterialer bruges som skjold mod bakterier og vira?
Er det muligt at skabe nye nanomaterialer, der kan danne overflader, som kan genkende og nedbryde skadelige bakterier eller vira? Det skal forsker fra Roskilde Universitet undersøge i nyt forskningsprojekt, som har fået 2 mio. kr. fra Villum Fonden.
Stof fra cannabisplanten kan bekæmpe MRSA
I nye resultater har forskere fra Roskilde Universitet påvist, at enkelte kemiske komponenter af cannabis har en virksom effekt mod multiresistente gule stafylokokker (MRSA) hos mennesker. Resultaterne bekræfter eksisterende forskning og tilføjer afgørende ny viden om, hvordan aktive molekyler fra cannabisplanten kan bruges i kombination med en række traditionelle antibiotika, der i dag bruges i behandling af MRSA hos mennesker. Resultaterne kan lægge grunden til udvikling af nye typer medicin, som kan mindske forbruget af konventionelle antibiotika og dæmpe udviklingen af antibiotikaresistens.
Gennembrud i behandling mod multiresistent tuberkulose
Bakterien, der udløser tuberkulose, bliver i stigende grad multiresistent over for kendte antibiotika-præparater. Men nu har forskere fra RUC sammen med udenlandske forskerkolleger udviklet og testet nye antimikrobielle stoffer, der kan bruges som alternativ til antibiotika i kampen mod den frygtede infektionssygdom tuberkulose
Smukke solceller skal stoppe global opvarmning
RUC-forsker deltager i udviklingen af en ny type solcelle, der er billigere og mere fleksibel end den velkendte silicium-solcelle. Han er overbevist om, at det bliver udnyttelsen af solenergi, der skal redde os fra den globale opvarmning.
Kemiker kan spare Danmark for millioner kroner
Kemiker John Mortensen fra RUC har været med til at udvikle en ny metode til at fjerne skadeligt stof fra byggerier. Det har i første omgang sparet Roskilde Kommune for 32 mio. kroner og kan give enorme besparelser over hele landet.
Base på RUC
Faggruppen hører hjemme på Institut for Naturvidenskab og Miljø
Relaterede forskningsenheder: FRUSTMI forskningscenter // Miljødynamik faggruppe // Molecular and Medical Biology faggruppe // Matematik og Fysik faggruppe
Ph.d.-skole: Doctoral School of Science and Environment
Uddannelser og fag: Kemi // Chemical Biology // Naturvidenskabelig Bachelor // International Bachelor in Natural Sciences
Forskning fra Roskilde Universitet
Mere om faggruppen
Mere viden om Kemi
Kontakt
Faggruppeleder
William Goldring
Lektor
Telefon +45 4674 2308
goldring@ruc.dk