Kemi

The Chemistry Research Group conducts fundamental and applied research in a variety of areas, and many of the research projects have strong connections with Chemical Biology. The sustainable development and application of chemistry is a common theme in our research, which drives many of our projects in green chemistry and energy, molecules of medicinal and biological interest, biophysical and protein chemistry, enzyme catalysis, and chemical characterization. Research efforts in these areas, for example, resulted in the development of new medicines and new chemical tools for studying biological molecules and processes, and molecular interactions. Through these research activities the next generation of scientists receive a training in fundamental and cutting edge theory, together with modern practical laboratory techniques and skills.

Key areas of interest include:

Biophysical and biological chemistry (protein structure and interactions by NMR, hydrogen bonding, oligomerization, fibril formation and gelation)
Enzymology (catalysis, hydrolytic enzymes)
Energy and sustainability (solar cell chemistry, biodegradable plastics, electrochemistry)
Organic synthesis and chemical biology (methods development, bioactive compounds and new medicines, bioconjugates, biopolymers, drug delivery systems)
Proteomics and Metabolomics (chemical characterization of biological processes, mass spectrometry, NMR and multivariate analysis)
Analytical chemistry (chromatography and mass spectrometry methods, sensor development)
Surface chemistry (development and characterization of peptoid nanosheets, molecular probes and interactions)

As an interdisciplinary hub, the Chemistry Group plays a key role in collaborative research projects conducted with internal and external academic partners working in areas such as; molecular, medical, and environmental biology, as well as mathematics and physics. The group is a founding member of the Roskilde University Center for Frustrated Molecular Interactions, which drives and conducts larger scale research programs. In addition to these activities, the group has many collaborations with major Danish and international research institutions and industrial partners.

Nyheder

Nyt kunstværk hædrer professor emeritus Poul Erik Hansens arbejde

09. februar 2022 |

I anledning af professor emeritus Poul Erik Hansens 75-års fødselsdag har kemi-faggruppen doneret kunstværket Chemophilia 1 til Roskilde Universitet. Kunstværket er skabt af den tyske kunstner Thomas Ruhland, som har hentet inspiration fra sit mangeårige arbejde som medicinalkemiker.

Kan nanomaterialer bruges som skjold mod bakterier og vira?

18. oktober 2021 | Nyhed

Er det muligt at skabe nye nanomaterialer, der kan danne overflader, som kan genkende og nedbryde skadelige bakterier eller vira? Det skal forsker fra Roskilde Universitet undersøge i nyt forskningsprojekt, som har fået 2 mio. kr. fra Villum Fonden.

Foto af arbejde ved HPLC-apparatur, der på RUC bruges til at separere CBD fra andre cannabismolekyler.

Stof fra cannabisplanten kan bekæmpe MRSA

06. oktober 2020 |

I nye resultater har forskere fra Roskilde Universitet påvist, at enkelte kemiske komponenter af cannabis har en virksom effekt mod multiresistente gule stafylokokker (MRSA) hos mennesker. Resultaterne bekræfter eksisterende forskning og tilføjer afgørende ny viden om, hvordan aktive molekyler fra cannabisplanten kan bruges i kombination med en række traditionelle antibiotika, der i dag bruges i behandling af MRSA hos mennesker. Resultaterne kan lægge grunden til udvikling af nye typer medicin, som kan mindske forbruget af konventionelle antibiotika og dæmpe udviklingen af antibiotikaresistens.

Kontakt

William Goldring, lektor, faggruppeleder, goldring@ruc.dk

Forskere

Frederik Diness, lektor, diness@ruc.dk

William Goldring, lektor, goldring@ruc.dk

Jeppe Kari, lektor, jkari@ruc.dk

Torben Lund, lektor, tlund@ruc.dk

Anders Malmendal, lektor, amalm@ruc.dk

Biljana Mojsoska, lektor, biljana@ruc.dk

Trine Holm Freiesleben, videnskabelig assistent, tholmf@ruc.dk

Jens Christian Sidney Schönbeck, videnskabelig assistent, jechsc@ruc.dk

Poul Erik Hansen, professor emeritus, poulerik@ruc.dk

Søren Hvidt, lektor emeritus, hvidt@ruc.dk

Jens Josephsen, lektor emeritus, phjens@ruc.dk

John Mortensen, lektor emeritus, john@ruc.dk

Jens Spanget-Larsen, lektor emeritus, spanget@ruc.dk

Forskere i faggruppen Kemi findes på Roskilde Universitets Forskningsportal
Based in a new building equipped with modern infra-structure, chemistry researchers in the DSC work with state-of-the-art instrumentation and analytical facilities, such as:

Mass Spectrometry

Associate Prof. Torben Lund (tlund@ruc.dk)
Associate Prof. Biljana Mojsoska (biljana@ruc.dk)
Rosa Jersie-Christensen, PhD (rrj@ruc.dk)

LC-MS

LTQ-XL Thermo Finnigan linear ion-trap mass spectrometer with a HESII electro spray ion source, coupled to a Dionex Ultimate 3000 UHPLC and a diode array detector.
Instrument use: Analysis of ruthenium dyes, natural products, intact proteins, peptides, organic reaction mixtures.

Q Exactive Plus, high resolution mass spectrometer coupled to a Dionex Ultimate 3000 nano-HPLC.
Instrument use: Proteomics and exact mass determinations.

GC-MS

Thermo Scientific Trace 1300 GC coupled to a ISQ-7000 EI-MS and a TDC detector. The instrument includes a Triplus RSH autosampler with PTV and head-space injection.
Instrument use: PCB and gas-molecule detection (H2, CO, CO2…).

Nuclear Magnetic Resonance (NMR) Spectrometer

Associate Prof. William Goldring (goldring@ruc.dk)
Associate Prof. Anders Malmendal (amalm@ruc.dk)
Operator: Annette Christensen (acis@ruc.dk)

Bruker Ascend 400 MHz, including auto-sampler and BCU II variable temperature control
Instrument use: Analysis of synthesis and natural products, biological material, and molecular complexes. Methods include, structure characterization and elucidation using a variety of routine and non-routine one- and two-dimensional experiments.

Dynamic Light Scattering (DLS)

Associate Prof. Søren Hvidt (hvidt@ruc.dk)

Malvern Zetasizer Nano-S
Instrument use: Analysis of nanoparticles, including materials and biological complexes, for particle size measurement and polydispersity determination.

Other instruments

The section is also equipped with a number of other instruments, such as infrared and UV spectrometers, preparative and analytical chromatographic equipment (HPLC, radial LC, size exclusion), rheometers (Bohlin VOR and Haake RS100), calorimeters (ITC and DSC), photochemical lamps (400 and 125 W medium pressure Hg) and reaction vessels, and chemical computation facilities (Gaussian and Macromodel).

Publikationer

A new sesquiterpene lactone from the leaves of Panax vietnamensis Ha et Grushv. (Vietnamese ginseng)
Le, H. K., Phan, T. T., Nguyen, T. M. N., Nguyen, T. C., Tran, C. L., Hansen, P. E. & That, Q. T., 2023, I: Natural Product Research. Latest Articles
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
Electrochemical sensors for screening of tyrosine and tryptophan as biomarkers for diseases: A narrative review
Nasimi, H., Madsen, J. S., Zedan, A. H., Malmendal, A., Osther, P. J. S. & Alatraktchi, F. A. Z. A., jul. 2023, I: Microchemical Journal. 190, 108737.
Publikation: Bidrag til tidsskrift › Review › peer review
Essentiality of the Escherichia coli YgfZ Protein for the In Vivo Thiomethylation of Ribosomal Protein S12 by the RimO Enzyme
Lund, T., Kulkova, M. Y., Jersie-Christensen, R. & Atlung, T., mar. 2023, I: International Journal of Molecular Sciences. 24, 5, 4728.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Flere publikationer

Aktiviteter

11th Peptoid Summit
Biljana Mojsoska (Deltager)
11 aug. 2022 → 13 aug. 2022
Aktivitet: Deltagelse i eller arrangering af en begivenhed › Deltagelse i workshop, seminar og kursus
-“Antimicrobial Drug Development-An ongoing investigation of the multiple applications of peptidomimetics”
Biljana Mojsoska (Oplægsholder)
14 jun. 2022
Aktivitet: Tale eller præsentation › Foredrag og mundtlige bidrag
Microbial Secondary Metabolites in Microbiomes 2022
Biljana Mojsoska (Deltager)
12 jun. 2022 → 14 jun. 2022
Aktivitet: Deltagelse i eller arrangering af en begivenhed › Deltagelse i workshop, seminar og kursus

Flere aktiviteter

Mere viden

ARTIKEL

Kan nanomaterialer bruges som skjold mod bakterier og vira?

Læs mere om Kan nanomaterialer bruges som skjold mod bakterier og vira?

Stof fra cannabisplanten kan bekæmpe MRSA

Læs mere om Stof fra cannabisplanten kan bekæmpe MRSA

ARTIKEL

Gennembrud i behandling mod multiresistent tuberkulose

Bakterien, der udløser tuberkulose, bliver i stigende grad multiresistent over for kendte antibiotika-præparater. Men nu har forskere fra RUC sammen med udenlandske forskerkolleger udviklet og testet nye antimikrobielle stoffer, der kan bruges som alternativ til antibiotika i kampen mod den frygtede infektionssygdom tuberkulose

Læs mere om Gennembrud i behandling mod multiresistent tuberkulose

ARTIKEL

Smukke solceller skal stoppe global opvarmning

RUC-forsker deltager i udviklingen af en ny type solcelle, der er billigere og mere fleksibel end den velkendte silicium-solcelle. Han er overbevist om, at det bliver udnyttelsen af solenergi, der skal redde os fra den globale opvarmning.

Læs mere om Smukke solceller skal stoppe global opvarmning

ARTIKEL

Kemiker kan spare Danmark for millioner kroner

Kemiker John Mortensen fra RUC har været med til at udvikle en ny metode til at fjerne skadeligt stof fra byggerier. Det har i første omgang sparet Roskilde Kommune for 32 mio. kroner og kan give enorme besparelser over hele landet.