Centre for Mathematical Modeling - Human Health and Disease
The goal of the Centre for Mathematical Modeling - Human Health and Disease (COMMAND) is to develop mathematical models to enhance understanding of human health and diseases. The methodology of mathematical modeling of human health and diseases is capable of improve diagnosis and treatments for the benefit of patients and society.
The interdisciplinary approach of mathematical modeling may elucidate the unseen and make the otherwise inaccessible accessible. We briefly denote this “the mathematical microscope”. We extract scientific insight into bio-medical mechanisms of health and diseases based on biological knowledge and data and use such insight to promote the development of digital tools for personalized diagnoses and therapy. Combining personalized data with mechanism based mathematical models may refines diagnoses, show benefits of early intervention, make timely therapies more effective, lead to new robust patient specific treatments, and result in individual treatment forecast for the benefit of patients and the health care system.
The insight gained by such interdisciplinary approach will generate solid theoretical foundation for quantitative biomedicine in accordance with experimental findings - on which future research and clinical procedures will be anchored.
Specifically, we have gained expert knowledge on mathematical modeling of several diseases in collaborating with medical doctors. Examples include: cancer development and cancer treatment strategies, e.g. for myeloproliferative neoplasms and their coupling to the immune system, where we have proven benefits of early intervention and have suggested data-driven improved combination treatments; the cardiovascular system and its regulation in relation to diseases such as heart failure, syncope, neuropathy, hypertension, we have developed hypotheses for developing POTS, and we have gain understanding of the intercranial pressure curve for severe head injured patients refining diagnoses and suggest individual treatment; diabetes type 1 and 2, where we have proposed a cure, which has subsequently been verified on mice; endocrine physiology especially the hypothalamic-pituitary-adrenal (HPA) axis we have pin pointed pathologies involved in stress and mental diseases; and developed models for flexible multi-pass dialysis methods versus conventional single-pass methods, which are immobile and thus inappropriate e.g. for traveling. Central for all these activities are the development and application of identification and parameter estimation for the complex dynamical systems considered.

-
Contact
Johnny T. Ottesen, Professor, head ofcentre, johnny@ruc.dk
Researchers
Researchers in Centre for Mathematical Modeling - Human Health and Disease (COMMAND)
-
Mathematical modeling of Acute Leukemia
Project leader: Thomas Stiehl, postdoc, contact@thomas-stiehl.de
Find projects at Roskilde Universitets Research Portal
Publications
A family with ulcerative colitis maps to 7p21.1 and comprises a region with regulatory activity for the aryl hydrocarbon receptor gene
Eiberg, H., Olsson, J. B., Bak, M., Bang-Berthelsen, C. H., Troelsen, J. T. & Hansen, L., 2023, In: European Journal of Human Genetics. Early ViewResearch output: Contribution to journal › Journal article › Research › peer-review
Analytical solution of phosphate kinetics for hemodialysis
Andersen, M., Bangsgaard, K. O., Heaf, J. G. & Ottesen, J. T., Jul 2023, In: Journal of Mathematical Biology. 87, 1, 22 p., 11.Research output: Contribution to journal › Journal article › Research › peer-review
Bayesian parameter estimation for phosphate dynamics during hemodialysis
Bangsgaard, K. O., Andersen, M., G. Heaf, J. & Ottesen, J. T., 2023, In: Mathematical Biosciences and Engineering. 20, 3, p. 4455-4492 38 p.Research output: Contribution to journal › Journal article › Research › peer-review
Activities
7th International Conference on the History and Philosophy of Computing (Event)
Jens Ulrik Hansen (Editor)
18 Oct 2023 → 20 Oct 2023Activity: Editorial work and peer review › Peer review of manuscripts › Research
Image analysis from a microscopist’s viewpoint
Pia Nyeng (Speaker)
12 May 2023Activity: Talk or presentation › Lecture and oral contribution
Multicellular crosstalk: Uncovering the interplay between pancreatic cell lineages by 3D live cell imaging and deep-learning assisted analysis
Pia Nyeng (Speaker)
10 Feb 2023Activity: Talk or presentation › Lecture and oral contribution
Press-media
Nu skal borgere afdække flåtbestanden i Danmark: Særligt i Nordsjælland vrimler det med dem
06/08/2023
2 items of Media coverage
Press/Media: Press / Media
Bliver du dårlig af at spise oksekød? Ny dansk forskning skal undersøge fænomenet
05/08/2023
1 item of Media coverage
Press/Media: Press / Media
Borgere hjælper med at kortlægge flåter i Danmark
03/08/2023
4 items of Media coverage
Press/Media: Press / Media
Funding
We are hosting
- a scholarship of DKK 10 million over five years from the Lundbeck Foundation Fellowship to the project Mathematical modeling of Acute Leukemia (2021-2025) (- artikel in Danish)
Insights
Teaching materials for high schools
Researchers from COMMAND have in collaboration with high school teachers prepared teaching materials in mathematical modeling for the high schools. The materials are in Danish and free to download.

Base at Roskilde University
The reseach centre is based at Department of Science and Environment
Participating research units: The Cancitis Research Group specialist group // PandemiX Center research centre // Centre for Big Data research centre // Reseach centre in Health Promation
PhD programmes: Doctoral School of Science and Environment
Relevant degree programmes: Mathematics // Molecular Biology // Mathematical Bioscience // International Bachelor in Natural Sciences
Research from Roskilde University

More about the centre
Additional information about Centre for Mathematical Modeling - Human Health and Disease (COMMAND):
The research centre at the Roskilde University Research Portal

Contact
Head of research centre
Johnny T. Ottesen
Professor
Phone: +45 4674 2298
johnny@ruc.dk