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Centre for Mathematical Modeling - Human Health and Disease

The goal of the Centre for Mathematical Modeling - Human Health and Disease (COMMAND) is to develop mathematical models to enhance understanding of human health and diseases. The methodology of mathematical modeling of human health and diseases is capable of improve diagnosis and treatments for the benefit of patients and society.

The interdisciplinary approach of mathematical modeling may elucidate the unseen and make the otherwise inaccessible accessible. We briefly denote this “the mathematical microscope”. We extract scientific insight into bio-medical mechanisms of health and diseases based on biological knowledge and data and use such insight to promote the development of digital tools for personalized diagnoses and therapy. Combining personalized data with mechanism based mathematical models may refines diagnoses, show benefits of early intervention, make timely therapies more effective, lead to new robust patient specific treatments, and result in individual treatment forecast for the benefit of patients and the health care system.

The insight gained by such interdisciplinary approach will generate solid theoretical foundation for quantitative biomedicine in accordance with experimental findings - on which future research and clinical procedures will be anchored.

Specifically, we have gained expert knowledge on mathematical modeling of several diseases in collaborating with medical doctors. Examples include: cancer development and cancer treatment strategies, e.g. for myeloproliferative neoplasms and their coupling to the immune system, where we have proven benefits of early intervention and have suggested data-driven improved combination treatments; the cardiovascular system and its regulation in relation to diseases such as heart failure, syncope, neuropathy, hypertension, we have developed hypotheses for developing POTS, and we have gain understanding of the intercranial pressure curve for severe head injured patients refining diagnoses and suggest individual treatment; diabetes type 1 and 2, where we have proposed a cure, which has subsequently been verified on mice; endocrine physiology especially the hypothalamic-pituitary-adrenal (HPA) axis we have pin pointed pathologies involved in stress and mental diseases; and developed models for flexible multi-pass dialysis methods versus conventional single-pass methods, which are immobile and thus inappropriate e.g. for traveling. Central for all these activities are the development and application of identification and parameter estimation for the complex dynamical systems considered.

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Funding

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Collaboration

Region Sjællands logo
Region Zealand
Region Hovedstaden logo
The Capital Region of Denmark
Danish Life Science Cluster logo
Danish Life Science Cluster
Greater Copenhagen Healts Science Partners logo
Greater Copenhagen Healts Science Partners (Clinical Academic Group -ZIRI)
Statens Serum Institut logo
Statens Serum Institut

Insights

ARTICLE

RUC receives 10 million DKK for research on mathematical modelling of blood cancer

Thomas Stiehl will be leading the research project that receives a fellowship of 10 million DKK from The Lundbeck Foundation. The project runs 5 years from January 1st, 2021.

Morten Andersen
ARTICLE

Mathematics Provides More Effective Cancer Treatment

Mathematicians at Roskilde University, in collaboration with hematologists at Zealand University Hospital, have developed mathematical models for how normal blood production, development of blood cancer and inflammation mutually affect each other. In synergy with blood samples from the individual patient, the models can provide a guide for more effective, individualised cancer treatment.

Johnny Ottesen
ARTICLE

Mathematical model can improve depression diagnosis

Mathematical models can be used to develop new methods to diagnose e.g. depression, and the models can provide important information to help develop better forms of treatment.

Teaching materials for high schools

Researchers from COMMAND have in collaboration with high school teachers prepared teaching materials in mathematical modeling for the high schools. The materials are in Danish and free to download.

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Overblik over forskning på RUC

Base at Roskilde University

The reseach centre is based at Department of Science and Environment

Participating research units: The Cancitis Research Group specialist group // PandemiX Center research centre // Centre for Big Data research centre // Reseach centre in Health Promation

PhD programmes: Doctoral School of Science and Environment

Relevant degree programmes: Mathematics // Molecular Biology // Mathematical Bioscience // International Bachelor in Natural Sciences
 

Research from Roskilde University

Research - overview

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More about the centre

Additional information about  Centre for Mathematical Modeling - Human Health and Disease (COMMAND):

The research centre at the Roskilde University Research Portal

Profil

Contact

Head of research centre

Johnny T. Ottesen
Professor
Phone: +45 4674 2298
johnny@ruc.dk