Funding
We are hosting
- a scholarship of DKK 10 million over five years from the Lundbeck Foundation Fellowship to the project Mathematical modeling of Acute Leukemia (2021-2025) (- artikel in Danish)
Centre for Mathematical Modeling - Human Health and Disease
The goal of the Centre for Mathematical Modeling - Human Health and Disease (COMMAND) is to develop mathematical models to enhance understanding of human health and diseases. The methodology of mathematical modeling of human health and diseases is capable of improve diagnosis and treatments for the benefit of patients and society.
The interdisciplinary approach of mathematical modeling may elucidate the unseen and make the otherwise inaccessible accessible. We briefly denote this “the mathematical microscope”. We extract scientific insight into bio-medical mechanisms of health and diseases based on biological knowledge and data and use such insight to promote the development of digital tools for personalized diagnoses and therapy. Combining personalized data with mechanism based mathematical models may refines diagnoses, show benefits of early intervention, make timely therapies more effective, lead to new robust patient specific treatments, and result in individual treatment forecast for the benefit of patients and the health care system.
The insight gained by such interdisciplinary approach will generate solid theoretical foundation for quantitative biomedicine in accordance with experimental findings - on which future research and clinical procedures will be anchored.
Specifically, we have gained expert knowledge on mathematical modeling of several diseases in collaborating with medical doctors. Examples include: cancer development and cancer treatment strategies, e.g. for myeloproliferative neoplasms and their coupling to the immune system, where we have proven benefits of early intervention and have suggested data-driven improved combination treatments; the cardiovascular system and its regulation in relation to diseases such as heart failure, syncope, neuropathy, hypertension, we have developed hypotheses for developing POTS, and we have gain understanding of the intercranial pressure curve for severe head injured patients refining diagnoses and suggest individual treatment; diabetes type 1 and 2, where we have proposed a cure, which has subsequently been verified on mice; endocrine physiology especially the hypothalamic-pituitary-adrenal (HPA) axis we have pin pointed pathologies involved in stress and mental diseases; and developed models for flexible multi-pass dialysis methods versus conventional single-pass methods, which are immobile and thus inappropriate e.g. for traveling. Central for all these activities are the development and application of identification and parameter estimation for the complex dynamical systems considered.
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Contact
Johnny T. Ottesen, Professor, head ofcentre, johnny@ruc.dk
Researchers
Researchers in Centre for Mathematical Modeling - Human Health and Disease (COMMAND)
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Mathematical modeling of Acute Leukemia
Project leader: Thomas Stiehl, postdoc, contact@thomas-stiehl.de
Find projects at Roskilde Universitets Research Portal
Publications
Cervids and raccoon dogs as wildlife sentinels for the geographical distribution of tick-borne encephalitis virus and Francisella tularensis in Denmark
Hansen, M. F., Sørensen, C. A., Lawson, K. A. B., Jedari, S. M., Stensgaard, A. S., Sengupta, M. E., Petersen, H. H. & Krogfelt, K. A., Mar 2025, In: Ticks and Tick-Borne Diseases. 16, 2, 102466.Research output: Contribution to journal › Journal article › Research › peer-review
Fritz Kauffmann: innovator in microbial classification
Jønsson, R., Ingholt, M. M. & Krogfelt, K. A., Jan 2025, In: APMIS. 133, 1, e13504.Research output: Contribution to journal › Review › peer-review
Indoor air quality and symptoms of acute respiratory infections and gastrointestinal issues in children and employees in day-care nurseries
Andrup, L., Kolarik, B., Klingenberg, A. M., Stephansen, L., Krogfelt, K. A. & Madsen, A. M., Apr 2025, In: American Journal of Infection Control. 53, 4, p. 458-466 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
Activities
Assessment committee chair, PhD-thesis evaluation committee
Hansen, J. U. (Examiner)
24 Oct 2024Activity: Examination
Kunstig intelligens som værktøjer i forskningsverdenen og menneskelig ekspertise
Hansen, J. U. (Speaker)
19 Sept 2024Activity: Talk or presentation › Lecture and oral contribution
Should we still be looking for echo chambers? A framework for studying polarization dynamics on social media
Hansen, J. U. (Speaker) & Mayerhöffer, E. (Speaker)
3 Sept 2024Activity: Talk or presentation › Lecture and oral contribution
Press-media
Derfor sultede forsøgspersoner i videnskabens navn
05/04/2025
1 item of Media coverage
Press/Media: Press / Media
Jonas Herby: Corona-nedlukningerne gjorde langt mere skade end gavn
30/01/2025
1 item of Media coverage
Press/Media: Press / Media
Klimakrisen kan koste sygdom og død i Danmark. Her er de fem største trusler
25/11/2024
1 item of Media coverage
Press/Media: Press / Media
Collaboration
Insights
Teaching materials for high schools
Researchers from COMMAND have in collaboration with high school teachers prepared teaching materials in mathematical modeling for the high schools. The materials are in Danish and free to download.
Base at Roskilde University
The reseach centre is based at Department of Science and Environment
Participating research units: The Cancitis Research Group specialist group // PandemiX Center research centre // Centre for Big Data research centre // Reseach centre in Health Promation
PhD programmes: Doctoral School of Science and Environment
Relevant degree programmes: Mathematics // Molecular Biology // Mathematical Bioscience // International Bachelor in Natural Sciences
Research from Roskilde University
More about the centre
Additional information about Centre for Mathematical Modeling - Human Health and Disease (COMMAND):
The research centre at the Roskilde University Research Portal
Contact
Head of research centre
Johnny T. Ottesen
Professor
Phone: +45 4674 2298
johnny@ruc.dk