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Chemistry

The Chemistry Research Group conducts fundamental and applied research in a variety of areas, and many of the research projects have strong connections with Chemical Biology. The sustainable development and application of chemistry is a common theme in our research, which drives many of our projects in green chemistry and energy, molecules of medicinal and biological interest, biophysical and protein chemistry, enzyme catalysis, and chemical characterization. Research efforts in these areas, for example, resulted in the development of new medicines and new chemical tools for studying biological molecules and processes, and molecular interactions. Through these research activities the next generation of scientists receive a training in fundamental and cutting edge theory, together with modern practical laboratory techniques and skills.

Key areas of interest include: 

  • Biophysical and biological chemistry (protein structure and interactions by NMR, hydrogen bonding, oligomerization, fibril formation and gelation)
  • Enzymology (catalysis, hydrolytic enzymes)
  • Energy and sustainability (solar cell chemistry, biodegradable plastics, electrochemistry)
  • Organic synthesis and chemical biology (methods development, bioactive compounds and new medicines, bioconjugates, biopolymers, drug delivery systems)
  • Proteomics and Metabolomics (chemical characterization of biological processes, mass spectrometry, NMR and multivariate analysis)
  • Analytical chemistry (chromatography and mass spectrometry methods, sensor development)
  • Surface chemistry (development and characterization of peptoid nanosheets, molecular probes and interactions)

As an interdisciplinary hub, the Chemistry Group plays a key role in collaborative research projects conducted with internal and external academic partners working in areas such as; molecular, medical, and environmental biology, as well as mathematics and physics. The group is a founding member of the Roskilde University Center for Frustrated Molecular Interactions, which drives and conducts larger scale research programs. In addition to these activities, the group has many collaborations with major Danish and international research institutions and industrial partners.

Kemi facilitet

News

Excerpt from the artwork Chemophilia 1 by Thomas Ruhland

New artwork honors the work of Professor Emeritus Poul Erik Hansen

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On the occasion of Professor Emiritus Poul Erik Hansen's 75th birthday, the Chemistry Research Group has donated the artwork Chemophilia 1 to Roskilde University. The artwork is created by the German artist Thomas Ruhland, who draws on inspiration from his many years of work as a medicinal chemist.
Biljana Mojsoska

Can nanomaterials be used as shields against bacteria and viruses?

| News
Is it possible to create new nanomaterials that can form surfaces capable of recognising and degrading harmful bacteria or viruses? Scientists from Roskilde University are about to investigate this in a new research project that has received DKK 2 million from Villum Experiment.
Picture of scientist using HPLC equipment to separate CBD from other cannabis molecules.

Substance derived from the cannabis plant can combat MRSA

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In new results, scientists from Roskilde University have shown that individual chemical components of cannabis have an effective impact on methicillin-resistant Staphylococcus aureus (MRSA). The results confirm existing research and add crucial new knowledge on how active molecules from the cannabis plant can be applied in combination with a number of traditional antibiotics currently used to treat MRSA in humans. The results could lay the groundwork for the development of new types of medicine that could reduce consumption of conventional antibiotics and curb the growth of antibiotic resistance.

  • Contact

    William Goldring, Associate Professor, Head of Chemistry Section, goldring@ruc.dk
     

    Reseachers

    Gustavo Penteado Battesini Carretero, Postdoc, gpbc@ruc.dk

    Frederik Diness, Associate Professor, diness@ruc.dk

    William Goldring, Associate Professor, goldring@ruc.dk

    Jeppe Kari, Associate Professor, jkari@ruc.dk

    Torben Lund, Associate Professor, tlund@ruc.dk

    Anders Malmendal, Associate Professor, amalm@ruc.dk

    Biljana Mojsoska, Associate Professor, biljana@ruc.dk

    Poul Erik Hansen, Professor Emeritus, poulerik@ruc.dk

    Søren Hvidt, Associate Professor Emeritus, hvidt@ruc.dk

    Jens Josephsen, Associate Professor Emeritus, phjens@ruc.dk

    John Mortensen, Associate Professor Emeritus, john@ruc.dk

    Jens Spanget-Larsen, Associate Professor Emeritus, spanget@ruc.dk
     

    Reseachers in Chemistry

  • Based in a new building equipped with modern infra-structure, chemistry researchers in the DSC work with state-of-the-art instrumentation and analytical facilities, such as:

    Mass Spectrometry

    Associate Prof. Torben Lund (tlund@ruc.dk)
    Associate Prof. Biljana Mojsoska (biljana@ruc.dk)
    Rosa Jersie-Christensen, PhD (rrj@ruc.dk)

    LC-MS

    LTQ-XL Thermo Finnigan linear ion-trap mass spectrometer with a HESII electro spray ion source, coupled to a Dionex Ultimate 3000 UHPLC and a diode array detector.
    Instrument use: Analysis of ruthenium dyes, natural products, intact proteins, peptides, organic reaction mixtures.

    Q Exactive Plus, high resolution mass spectrometer coupled to a Dionex Ultimate 3000 nano-HPLC.
    Instrument use: Proteomics and exact mass determinations.

    GC-MS

    Thermo Scientific Trace 1300 GC coupled to a ISQ-7000 EI-MS and a TDC detector. The instrument includes a Triplus RSH autosampler with PTV and head-space injection.
    Instrument use: PCB and gas-molecule detection (H2, CO, CO2…).

    Nuclear Magnetic Resonance (NMR) Spectrometer

    Associate Prof. William Goldring (goldring@ruc.dk)
    Associate Prof. Anders Malmendal (amalm@ruc.dk)
    Operator: Annette Christensen (acis@ruc.dk)

    Bruker Ascend 400 MHz, including auto-sampler and BCU II variable temperature control
    Instrument use: Analysis of synthesis and natural products, biological material, and molecular complexes. Methods include, structure characterization and elucidation using a variety of routine and non-routine one- and two-dimensional experiments.

    Dynamic Light Scattering (DLS)

    Associate Prof. Søren Hvidt (hvidt@ruc.dk)

    Malvern Zetasizer Nano-S
    Instrument use: Analysis of nanoparticles, including materials and biological complexes, for particle size measurement and polydispersity determination.

    Other instruments

    The section is also equipped with a number of other instruments, such as infrared and UV spectrometers, preparative and analytical chromatographic equipment (HPLC, radial LC, size exclusion), rheometers (Bohlin VOR and Haake RS100), calorimeters (ITC and DSC), photochemical lamps (400 and 125 W medium pressure Hg) and reaction vessels, and chemical computation facilities (Gaussian and Macromodel).

Publications

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Activities

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Insights

Biljana Mojsoska
ARTICLE

Can nanomaterials be used as shields against bacteria and viruses?

Is it possible to create new nanomaterials that can form surfaces capable of recognising and degrading harmful bacteria or viruses? Scientists from Roskilde University are about to investigate this in a new research project that has received DKK 2 million from Villum Experiment.

Picture of scientist using HPLC equipment to separate CBD from other cannabis molecules.

Substance derived from the cannabis plant can combat MRSA

In new results, scientists from Roskilde University have shown that individual chemical components of cannabis have an effective impact on methicillin-resistant Staphylococcus aureus (MRSA). The results confirm existing research and add crucial new knowledge on how active molecules from the cannabis plant can be applied in combination with a number of traditional antibiotics currently used to treat MRSA in humans. The results could lay the groundwork for the development of new types of medicine that could reduce consumption of conventional antibiotics and curb the growth of antibiotic resistance.

Biljana Mojsoska
ARTICLE

Breakthrough in the search for a new treatment for multi-drug resistant tuberculosis

Chemist Biljana Mojsoska and molecular biologist Håvard Jenssen from Roskilde University have in collaboration with international research colleagues developed and tested new antimicrobial drugs that can be used as an alternative to antibiotics in the fight against the infectious disease tuberculosis. The mycobacteria that triggers tuberculosis develops resistance to more and more known antibiotics.

Overblik over forskning på RUC

Base at Roskilde University

The research groupis based at Department of Science and Environment

Related research units: FRUSTMI research centre // Environmental Dynamics research group // Molecular and Medical Biology research group // Mathematics and Physics research group

PhD Programme: Doctoral School of Science and Environment

Uddannelser og fag: Chemistry // Chemical Biology // International Bachelor in Natural Sciences

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More information

Find additional information about Chemistry:

Research group website at Roskilde University Research Portal

Profil

Contact

Research group leader

William Goldring
Associate Professor
Phone +45 4674 2308
goldring@ruc.dk