IMFUFA-seminar om Cell Polarities and Development of Animal Morphologies
Mød Kim Sneppen fra Niels Bohr institutet på dette IMFUFA seminar, hvor han vil tale om Cell Polarities and Development of Animal Morphologies
Despite continual renewal and damages, a multicellular organism is able to maintain its complex morphology. How is this stability compatible with the complexity and diversity of living forms?
Looking for answers at protein level may be misleading as diverging protein sequences anyway can result in similar morphologies. Inspired by the progressive role of apical-basal and planar cell polarity in development, we propose that stability, complexity, and diversity are emergent properties in populations of polarized cells.
We support our hypothesis by a theoretical approach, developed to deal with both types of polar cell adhesions. When applied to specific developmental stages - gastrulation and the origins of folds and tubes – our model suggests that these can be directed by an interplay between the types of polar adhesion.
An interplay that are guided by restricted directions of cell polarities, and the rate of cell proliferation. Finally we discuss how the two polarities allow us to model formation of networks of blood vessel.
Seminaret foregår på engelsk.
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