IMFUFA-seminar: NMR and multivariate analysis in biological and biophysical systems
My most important research tools are nuclear magnetic resonance spectroscopy (NMR), which provides information on almost every atom in a molecule or a mixture of molecules, and multivariate analysis (MVA), which is very useful to make sense of this complex information.
The combination of NMR and MVA is traditionally explored in metabolomics, where MVA is used to identify the underlying biological processes from NMR-snapshots of all the small molecule metabolites in a number of biological samples obtained under different conditions.
For macromolecules one can record NMR spectra as a function of time and use multivariate methods to decipher time-courses of events such as the emergence of new structures and exchange between various species in solution.
Here I will tell you a bit about these tools, including how NMR can be used to monitor molecular size, structure, and dynamics, and provide examples describing macromolecular oligomerization and metabolic processes.
Seminaret foregår på engelsk.
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