IMFUFA-seminar on diffusion as a probe of brain microstructure
Meet Sune Jespersen Department of Clinical Medicine and Department of Physics and Astronomy Aarhus University who will talk about diffusion as a probe of brain microstructure.
Nuclear magnetic resonance (NMR) and magnetic resonance imaging (MRI) can be sensitized to the diffusion of spins, specifically the propagator (or Green’s function). The aim of micro-structural imaging is to exploit the sensitivity to predict and map microstructural properties of e.g. the brain noninvasively, a kind of virtual histology with obvious applications in neuroscience and medicine. The success of microstructural imaging depends critically on adequate biophysical modeling of the diffusion in the brain, which will be the focus of this talk. The starting point will be the so-called “Standard Model” of diffusion in the brain, a multiple Gaussian compartments (MGC) model thought to be valid in the long time regime. I will then discuss the process of coarse graining leading to deviations from MGC, such as diffusion time dependence, and new universality classes recently discovered, describing the approach to the long time regime. Novel diffusion pulse sequences will be introduced, which sensitize the diffusion signal to correlations not captured by the standard diffusion pulse sequence, and their time-dependent properties will be derived within the picture of coarse graining. The theoretical predictions will be compared to experimental results and to computer simulations in tissue models.
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